{"id":19744,"date":"2023-04-13T14:47:03","date_gmt":"2023-04-13T05:47:03","guid":{"rendered":"https:\/\/nitto-stainless.com\/en\/?page_id=19744"},"modified":"2023-06-15T16:15:01","modified_gmt":"2023-06-15T07:15:01","slug":"gmp-02","status":"publish","type":"page","link":"https:\/\/monovate.net\/en\/gmp-02\/","title":{"rendered":"Reasons for the Abandonment of Resin Containers"},"content":{"rendered":"<h2>Are Plastic Containers Really Safe to Use?<\/h2>\n<h3>Reasons Why Pharmaceutical Manufacturers Have Stopped Using Plastic Containers<\/h3>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-3604\" src=\"\/en\/wp-content\/uploads\/p_pori.jpg\"\n        alt=\"p_pori\" width=\"144\" height=\"140\" \/><\/p>\n<p>Why have plastic containers become obsolete?<br \/>\n    It is because they pose the following risks:<\/p>\n<p><strong><span style=\"font-size: 16px;\">1. The rough surface of plastic containers can introduce foreign<br \/>\n            substances.<br \/>\n        <\/span><span style=\"font-size: 16px;\">2. It is difficult to determine if the containers are effectively<br \/>\n            cleaned.<br \/>\n        <\/span><span style=\"font-size: 16px;\">3. Plastic containers are not recyclable (or difficult to<br \/>\n            recycle).<\/span><\/strong><\/p>\n<p><span style=\"font-size: 16px;\">Despite these risks, there is still a current situation where plastic containers are<br \/>\n        used for storage, handling, and transportation purposes, which are outside the scope of pharmaceutical<br \/>\n        GMP.<\/span><span style=\"font-size: 16px;\">Is this really acceptable?<\/span><\/p>\n<h3><span style=\"font-size: 20px;\">We Conducted a Swab Test on Stainless Steel Containers and Plastic Containers<\/span><br \/>\n<\/h3>\n<h4>Test Method<\/h4>\n<div class=\"content-column one_sixth\"><img decoding=\"async\" class=\"alignnone size-full wp-image-3610\"\n        src=\"\/en\/wp-content\/uploads\/test.jpg\" alt=\"test\" width=\"102\" height=\"90\" \/><\/div>\n<div class=\"content-column five_sixth last_column\">\n<p>1. Draw text on the surfaces of stainless steel containers and plastic (polyethylene) containers using an<br \/>\n        oil-based marker.<br \/>\n        2. Allow the ink to dry for 30 minutes.<br \/>\n        3. Use alcohol or similar substance to swab the surface and check for ink residue. <\/p>\n<\/div>\n<div class=\"clear_column\"><\/div>\n<p>The left side shows the stainless steel container, and the right side shows the resin (polyethylene) container.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-21045\" src=\"\/en\/wp-content\/uploads\/gmp-02-test.jpg\" alt=\"gmp-02-test\"\n        width=\"760\" height=\"400\" \/><\/p>\n<p>The stainless steel container was able to be wiped clean, but the resin (polyethylene) container had slight ink<br \/>\n    residue.<\/p>\n<p><strong><span style=\"font-size: 20px;\">From these results, it is clear that<\/span><span style=\"font-size: 20px;\"><br \/>\n            resin containers should not be used in environments where quality assurance is important.<\/span><\/strong>\n<\/p>\n<p>In the pharmaceutical industry, there is an increasing demand for stainless steel containers to comply with<br \/>\n    management regulations such as ISO and pharmaceutical GMP. Particularly, the adoption of electropolishing (EP) has<br \/>\n    become more prominent among major pharmaceutical manufacturers.<\/p>\n<h3><strong>Stainless Steel Containers for HACCP Compliance<\/strong><\/h3>\n<p>Even in the food industry, there is a high level of emphasis on hygiene management related to &#8220;food safety,&#8221; such as<br \/>\n    HACCP. As part of these efforts, a shift from resin containers to stainless steel containers has been taking place.\n<\/p>\n<h4>What is HACCP?<\/h4>\n<p>HACCP (Hazard Analysis and Critical Control Points) is a system that identifies potential hazards at every stage,<br \/>\n    monitors and records critical control points to prevent the occurrence of hazards, and enables prompt actions and<br \/>\n    prevention of shipping defective products.<\/p>\n<p><a href=\"\/archives\/technic\/haccp\/\">> Technical Column: &#8220;What should we do? Stainless Steel Containers and Getting<br \/>\n        Started with HACCP Guide&#8221;<\/a><\/p>\n<h3>Why is the transition to stainless steel containers progressing?<\/h3>\n<p>This is because stainless steel is a strong and corrosion-resistant material, and it has excellent fire resistance,<br \/>\n    low-temperature characteristics, processability, and hygiene. Furthermore, it is 100% recyclable and does not<br \/>\n    produce dioxins.<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3628\" src=\"\/en\/wp-content\/uploads\/sus1.jpg\"\n        alt=\"sus1\" width=\"180\" height=\"159\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3629\"\n        src=\"\/en\/wp-content\/uploads\/sus2.jpg\" alt=\"sus2\" width=\"170\" height=\"159\" \/><\/p>\n<h3><span style=\"font-size: 20px;\">Stainless steel containers have the following characteristics:<\/span><\/h3>\n<ul>\n<li><span style=\"font-size: 12pt;\">Smooth surface without crevices<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">Recyclable and environmentally friendly<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">Durable and resistant to rust due to its metal composition<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>Our stainless steel containers also have additional features:<\/h4>\n<ul>\n<li><span style=\"font-size: 12pt;\">Welding techniques prevent liquid or powder accumulation in the edges and<br \/>\n            handles<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">Use of specially developed stainless steel material enables finishing comparable<br \/>\n            to buff polishing<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">The use of thin stainless steel sheets allows for lightweight containers<\/span>\n    <\/li>\n<\/ul>\n<p><a href=\"\/gmp\">Learn more here<\/a><\/p>\n<h2>The Most Used Stainless Steel Containers in Pharmaceutical Manufacturing<\/h2>\n<p style=\"text-align: center;\"><img decoding=\"async\" src=\"\/en\/wp-content\/uploads\/SMA-CTL_01.jpg\" alt=\"\" width=\"300\" \/><\/p>\n<p>Containers used for storage, handling, and transportation, which greatly impact the quality of pharmaceuticals,<br \/>\n    should be managed at the same level as the production process of active ingredients and formulations. We highly<br \/>\n    recommend the all-stainless sealed container <a href=\"\/en\/products\/sma-ctl\/\">&#8220;SMA-CTL-47H&#8221;<\/a>, which is widely<br \/>\n    adopted by pharmaceutical manufacturers.<\/p>\n<p style=\"text-align: center;\"><a class=\"sub-contact_btn\" href=\"\/en\/products\/sma-ctl\/\">View Product Details<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Are Plastic Containers Really Safe to Use? Reasons Why Pharmaceutical Manufacturers Have Stopped Using Plastic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-19744","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/pages\/19744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/comments?post=19744"}],"version-history":[{"count":3,"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/pages\/19744\/revisions"}],"predecessor-version":[{"id":37969,"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/pages\/19744\/revisions\/37969"}],"wp:attachment":[{"href":"https:\/\/monovate.net\/en\/wp-json\/wp\/v2\/media?parent=19744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}