Solving aging-equipment challenges at once| Engineering away rust risk and human error


Challenge
Quality risk from rust on equipment used for about 30 years, plus production disruption risk due to glass-ball filter breakage (about once in every 10 runs).
Solution
Leveraged MONOVATE’s customization capability. Improved corrosion resistance and cleanability with electrolytic polishing inside the tank, and prevented trouble through a dedicated hanger design for the glass-ball filter.
Impact
Achieved more stable operations and reduced operator-to-operator variability through the dedicated hanger design. Met stringent hygiene requirements for pharmaceutical manufacturing and improved operational efficiency.
Pharmaceutical Manufacturer
A specialized manufacturer producing pharmaceuticals in cleanroom environments, with strict quality standards and hygiene requirements in the manufacturing area.

Background to the equipment renewal

Q What led you to start renewing this equipment?
The equipment we had been using for many years had become significantly worn. After we requested parts replacement, we decided it was time to renew the equipment.

Pharmaceutical mixing tank installation site

The newly installed sanitary tank

Long-standing issues and on-site challenges

Q What problems did you face day to day with the existing equipment?
We use purified water as a raw material, but with the existing tank we were concerned about rust and its potential impact on product quality, which also caused anxiety during inspections.

In addition, we insert a glass-ball filter (a glass component used in the bubbling system to increase dissolved oxygen) inside the tank. When we used the agitator, there were cases where the filter contacted the agitator, creating a breakage risk (about once in every 10 runs). This was a serious issue in terms of hygiene and raw material loss.

Issues with the existing tank

The previously used tank

Issues with the existing tank

Glass-ball filter

Why MONOVATE was selected and how we supported

Q What made you choose MONOVATE among several manufacturers?
The biggest deciding factor was MONOVATE’s ability to propose a customized solution based on a solid understanding of our on-site issues.

Because we did not want to change the existing manufacturing process significantly, MONOVATE proposed a “brush-up” approach to improve the tank while preserving our current operation. We also appreciated the proposal to reduce the glass-ball filter breakage risk, including the agitator’s shape and positioning, and a dedicated hanger to support the filter.

Issues with the existing tank

Inserting the dedicated hanger

Solution through customized design

Problem prevention through the dedicated hanger design
We can design from a single unit to fit your production process.

Discuss customization for pharmaceutical manufacturing tanks

Expected impact and next steps

Q What improvements do you expect from the new equipment?
Because we manufacture pharmaceuticals, hygiene is critically important. The new tank has an electrolytically polished interior, and we expect a significant improvement in corrosion resistance and cleanability compared with the existing tank.

Previously, the method of installing the glass-ball filter varied by operator. With the dedicated hanger, we can greatly reduce human error and proceed with daily manufacturing operations with greater confidence.

Q What are your next steps?
Through this project, we learned more about MONOVATE’s responsiveness and customization capability. We will continue renewing equipment in the future, and we would be glad to consult with MONOVATE again. Overall, we are very satisfied with the introduction of this tank.

MONOVATE note

Thank you for selecting MONOVATE for this project. By addressing two concrete issues—rust risk on equipment used for around 30 years and the breakage risk of the glass-ball filter—we were able to propose a fundamentally effective solution through customized design. We combined improved corrosion resistance and cleanability via electrolytic polishing with a dedicated hanger design to reduce operator-dependent variation and help prevent human error. We will continue strengthening our technical capability to support stringent quality requirements in pharmaceutical manufacturing.

Design and validation documents for pharmaceutical manufacturing—handled in one package

Liquid preparation tanks for the pharmaceutical industry
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